Absolutely gutted by the end of the second season, since I was convinced/hoping that Tom and Harry were setting up Christine, and that Zoe and Danny were out of the loop to be more convincing. Nope.
I thought the VX episode was good, but mistaken, since obviously it's a drill, because there's still another three episodes to go. Consequently, much of the British population are unlikely to be outside, lying dead in the streets. As a season closer, it would have had much more impact.
Alexander Siddig's episode was fantastic, as was he, but I was disappointed that Hugh Laurie didn't reprise his role as Jules; I guess House had kicked off by then.
Now, just got Season 1 of Futurama to watch and return...